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Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare

Yong Li,Yuhong Huang,Nan Feng,Heping Zhang,Jing Qu,Shuanggang Ma,Yunbao Liu,Jiang Li,Shaofeng Xu,Ling Wang,Mi Zhang,Jie Cai,Weiping Wang,Ru Feng,Hang Yu,Bo Yu,Dailiang Liang,Heping Qin,Suxiang Luo,Yanfen Li,

Engineering doi: 10.1016/j.eng.2023.09.017

Abstract: Bear bile has been a valuable and effective medicinal material in traditional Chinese medicine (TCM)Here, we present a new approach for creating artificial bear bile (ABB) as a high-quality and sustainablealternative to natural bear bile.This study addresses the scientific challenges of creating bear bile alternatives through interdisciplinaryThe resulting ABB not only closely resembles natural bear bile in its composition but also offers advantages

Keywords： Artificial bear bile     Chemical profile     Formula optimization     Pharmacodynamic consistency     Preclinical toxicological    

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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract:

Bile duct injury is a common complication of cholecystectomy.The timing of bile duct injury repair remains controversial.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommendedPercutaneous drainage of bile and endoscopic stenting are the mainstays of treatment of bile leak becausethey convert acute bile duct injury into a controlled external biliary fistula.

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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Bile acids and their effects on diabetes

Cynthia Rajani, Wei Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 608-623 doi: 10.1007/s11684-018-0644-x

Abstract: Manipulation of bile acid (BA) receptors and the BA pool have been shown to be useful in establishing

Keywords： bile acids     metabolic memory     diabetes     circadian rhythm     bariatric surgery    

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Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones

Zongming Zhang, Zhuo Liu, Limin Liu, Mengmeng Song, Chong Zhang, Hongwei Yu, Baijiang Wan, Mingwen Zhu, Zixu Liu, Hai Deng, Haiming Yuan, Haiyan Yang, Wenping Wei, Yue Zhao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 576-589 doi: 10.1007/s11684-017-0536-5

Abstract: method, effect, and complications of minimally invasive treatment of intrahepatic and extrahepatic bileduct stones by combining our practical experience were summarized as follows. (1) For intrahepatic bileduct stones, the operation may be selected by laparoscopic liver resection, laparoscopic common bilesphincterotomy (EST) or endoscopic papillary balloon dilatation, LC plus laparoscopic transcystic common bileplus LCBDE, and T-tube drainage or primary suture. (3) For concomitant intrahepatic and extrahepatic bile

Keywords： laparoscopy     choledochoscopy     duodenoscopy     cholelithiasis     minimally invasive treatment    

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A mini review: Shape memory polymers for biomedical applications

Kaojin Wang, Satu Strandman, X. X. Zhu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 2,   Pages 143-153 doi: 10.1007/s11705-017-1632-4

Abstract: Shape memory polymers (SMPs) are smart materials that can change their shape in a pre-defined manner under a stimulus. The shape memory functionality has gained considerable interest for biomedical applications, which require materials that are biocompatible and sometimes biodegradable. There is a need for SMPs that are prepared from renewable sources to be used as substitutes for conventional SMPs. In this paper, advances in SMPs based on synthetic monomers and bio-compounds are discussed. Materials designed for biomedical applications are highlighted.

Keywords： shape memory polymer     biodegradability     biocompatibility     biomedical application     bile acids    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 729-746 doi: 10.1007/s11684-022-0978-2

Abstract: Mechanistically, hepatocyte-specific Yap1 knockout (Yap1LKO) maintained bile

Keywords： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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Applications of traditional pump design theory to artificial heart and CFD simulation

WANG Yingpeng, SONG Xinwei, YING Chuntong

Frontiers in Energy 2008, Volume 2, Issue 4,   Pages 504-507 doi: 10.1007/s11708-008-0059-5

Abstract: traditional axial pump design theory with the consideration of working and hydraulic situations for artificialThe results show that this procedure can be used for designing a series of high-efficiency artificial

Keywords： computational     high-efficiency artificial     iterative approach     artificial     traditional    

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INTERACTIVE KNOWLEDGE LEARNING BY ARTIFICIAL INTELLIGENCE FOR SMALLHOLDERS

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 4,   Pages 648-653 doi: 10.15302/J-FASE-2023505

Abstract: Therefore, this article proposes an interactive knowledge learning approach using artificial intelligence

Keywords： artificial intelligence     extension system     non-point source pollution control     smallholders     fertilization    

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Artificial intelligence in gastroenterology: where are we heading?

Joseph JY Sung, Nicholas CH Poon

Frontiers of Medicine 2020, Volume 14, Issue 4,   Pages 511-517 doi: 10.1007/s11684-020-0742-4

Abstract: Artificial intelligence (AI) is coming to medicine in a big wave.

Keywords： artificial intelligence     endoscopy     robotics     gastrointestinal diseases    

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The Tong Test: Evaluating Artificial General Intelligence Through Dynamic Embodied Physical and Social

Yujia Peng,Jiaheng Han,Zhenliang Zhang,Lifeng Fan,Tengyu Liu,Siyuan Qi,Xue Feng,Yuxi Ma,Yizhou Wang,Song-Chun Zhu,

Engineering doi: 10.1016/j.eng.2023.07.006

Abstract: The release of the generative pre-trained transformer (GPT) series has brought artificial general intelligence(AGI) to the forefront of the artificial intelligence (AI) field once again.

Keywords： Artificial general intelligence     Artificial intelligence benchmark     Artificial intelligence evaluation     Embodied artificial intelligence     Value alignment     Turing test     Causality    

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Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 645-657 doi: 10.1007/s11684-018-0645-9

Abstract: microbiota-mediated development of NAFLD include modulation of host energy metabolism, insulin sensitivity, and bile

Keywords： gut microbiota     NAFLD     obesity     insulin resistance     bile acids     probiotic    

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Visible light responsive photocatalysts developed by substitution with metal cations aiming at artificial

Frontiers in Energy 2021, Volume 15, Issue 3,   Pages 568-576 doi: 10.1007/s11708-021-0774-8

Abstract: Solar hydrogen production by water splitting using a photocatalyst as artificial photosynthesis is a

Keywords： visible light responsive photocatalyst     water splitting     artificial photosynthesis: metal ion substitution    

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Special issue: Innovative applications of big data and artificial intelligence

Frontiers of Engineering Management 2022, Volume 9, Issue 4,   Pages 517-519 doi: 10.1007/s42524-022-0234-0

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Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 153-157 doi: 10.1007/s11684-009-0034-5

Abstract: To clarify the effect of DNA methylation and histone deacetylase inhibitors on the expression of the E-cadherin gene and the invasiveness of the QBC cells, the QBC cells were separately treated with hydralazine, valproate, or combination of the two drugs. The mRNA expression of E-cadherin was examined with reverse transcription-polymerase chain reaction (RT-PCR), the protein of the gene with Western blotting. The methylation status of the promoter region of the gene was detected with methylation-specific PCR (MSP). The invasiveness of QBC cells was detected with transwell assay. It was found that the promoter region of the E-cadherin gene of QBC cells was hypermethylated. Valproate alone could not contribute to demethylation of the gene, whereas hydralazine could make them to be partly demethylated. However, the methylation status of the gene could be thoroughly reversed by using valproate and hydralazine in combination. What’s more, it was confirmed that the E-cadherin gene of QBC cells could not be transcriptionally reactivated by Valproate alone, whereas hydralazine alone could induce moderate reexpression of the gene. However, using valproate and hydralazine in combination could result in robust reexpression of the E-cadherin gene ( =0.000). Likewise, the invasiveness of the QBC939 cells was sharply decreased by treatment with two drugs in combination and slightly decreased with one drug alone. It could be concluded that the two drugs have synergistic effect on the demethylation and reexpression of the E-cadherin gene of QBC cells, and also on the reduction of the invasiveness of the QBC939 cells.

Keywords： DNA methylation inhibitor     histone deacetylase inhibitor     bile duct carcinoma     E-cadherin    

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What will the future hold for artificial organs in the service of assisted reproduction: prospects and

Mara Simopoulou, Konstantinos Sfakianoudis, Petroula Tsioulou, Anna Rapani, Polina Giannelou, Nikolaos Kiriakopoulos, Agni Pantou, Nikolaos Vlahos, George Anifandis, Stamatis Bolaris, Konstantinos Pantos, Michael Koutsilieris

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 627-638 doi: 10.1007/s11684-019-0697-5

Abstract: Cutting edge research on animal models introduced this concept, along with the development of artificialTo date, the successful clinical application of artificial reproductive organs in humans is not feasibleThe application of these artificial organs could provide a solution to infertility cases with no otheron the current status, future prospects, and considerations on the potential clinical application of artificial

Keywords： artificial ovary     artificial uterus     artificial gametes     assisted reproduction     considerations     in vitro    

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Title Author Date Type Operation

Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare

Yong Li,Yuhong Huang,Nan Feng,Heping Zhang,Jing Qu,Shuanggang Ma,Yunbao Liu,Jiang Li,Shaofeng Xu,Ling Wang,Mi Zhang,Jie Cai,Weiping Wang,Ru Feng,Hang Yu,Bo Yu,Dailiang Liang,Heping Qin,Suxiang Luo,Yanfen Li,

Journal Article

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

Bile acids and their effects on diabetes

Cynthia Rajani, Wei Jia

Journal Article

Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones

Zongming Zhang, Zhuo Liu, Limin Liu, Mengmeng Song, Chong Zhang, Hongwei Yu, Baijiang Wan, Mingwen Zhu, Zixu Liu, Hai Deng, Haiming Yuan, Haiyan Yang, Wenping Wei, Yue Zhao

Journal Article

A mini review: Shape memory polymers for biomedical applications

Kaojin Wang, Satu Strandman, X. X. Zhu

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy

Journal Article

Applications of traditional pump design theory to artificial heart and CFD simulation

WANG Yingpeng, SONG Xinwei, YING Chuntong

Journal Article

INTERACTIVE KNOWLEDGE LEARNING BY ARTIFICIAL INTELLIGENCE FOR SMALLHOLDERS

Journal Article

Artificial intelligence in gastroenterology: where are we heading?

Joseph JY Sung, Nicholas CH Poon

Journal Article

The Tong Test: Evaluating Artificial General Intelligence Through Dynamic Embodied Physical and Social

Yujia Peng,Jiaheng Han,Zhenliang Zhang,Lifeng Fan,Tengyu Liu,Siyuan Qi,Xue Feng,Yuxi Ma,Yizhou Wang,Song-Chun Zhu,

Journal Article

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Journal Article

Visible light responsive photocatalysts developed by substitution with metal cations aiming at artificial

Journal Article

Special issue: Innovative applications of big data and artificial intelligence

Journal Article

Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Journal Article

What will the future hold for artificial organs in the service of assisted reproduction: prospects and

Mara Simopoulou, Konstantinos Sfakianoudis, Petroula Tsioulou, Anna Rapani, Polina Giannelou, Nikolaos Kiriakopoulos, Agni Pantou, Nikolaos Vlahos, George Anifandis, Stamatis Bolaris, Konstantinos Pantos, Michael Koutsilieris

Journal Article